Pedal the Cause, presented by Edward Jones, is thrilled to return for its 12th year of raising critical funds for cancer research with an exciting lineup of cycling and community events. Ride weekend will take place Saturday, September 25 and Sunday, September 26. Participants will choose from a variety of in-person and remote options, including three new bike courses and the popular Inspired option introduced in 2020. Registration for Pedal the Cause 2021 opens to the public on Thursday, April 1. One hundred percent of funds raised from Pedal the Cause support cancer research at Siteman Cancer Center and Siteman Kids at St. Louis Children’s Hospital.

“In the midst of a pandemic, Pedal the Cause supporters near and far rallied around our cause to raise more than $3 million for cancer research in 2020,” said Pedal the Cause Executive Director David Drier. “We are pleased to welcome our community back in 2021 as safely as possible for another successful year supporting innovative research at Siteman Cancer Center. Whether out on the trail, on Zwift, or at home, with each dollar raised we are closer to creating a world without cancer.”

In-person options for 2021 include four courses on Saturday, September 25 and three Spin Zone sessions and four course options on Sunday, September 26. Saturday’s courses feature two brand-new gravel rides and Sunday will include a new 30-mile road ride.

Back by popular demand, the Inspired option allows participants to create their own activity challenge and complete it prior to the fundraising deadline of October 31. In 2020, participants across the country chose to walk, run, bike, swim, and hike in honor of Pedal the Cause. Inspired will also include the option to join a virtual Spin Zone session on Sunday, September 26.

Due to the COVID-19 pandemic, some signature Pedal the Cause events will be held remotely or modified. The PTC Kids Challenge will be held as a virtual option in 2021. A car parade will be held on Saturday, September 11 celebrating Kids Challenge and Ride for a Child participants and their families. The Inspirational Program will be live-streamed the evening of Saturday, September 25.

In-person rides will feature a number of safety measures, including staggered start times for each race, to maintain social distancing, modified refueling stations, increased cleaning, and sanitizer stations and other measures as recommended by the St. Louis County Health Department. Pedal the Cause has also formed a COVID-19 Medical Advisory Committee to provide additional guidance and support.

Pedal the Cause brings back its popular Wellness Series with a variety of online and socially-distanced community events. Participants can tune in to the quarterly Medical Q&A Series and Chef’s Series throughout the year. Pedal the Cause will also offer socially-distanced training rides in the spring and summer months. A World Without Cancer Day will return on Friday, August 6.

“With so many exciting opportunities for participants and their donors throughout the year, it’s a great time to get involved with Pedal the Cause,” said Ashley Saitta, director of events. “There’s something for everyone and countless ways to support cancer research throughout the year.”

Registration for Inspired is $50. For in-person options, registration is $75 for one day and $110 for two days. Registration for kids is $15. More information about registration and participation options for 2021 can be found at

Pedal the Cause 2021 Event Schedule

April 1 : Registration Opens
May 18 : Medical Q&A Series | Session 2
July 1 : Fundraising commitment minimums increase
August 6 : A World Without Cancer Day
August 17 : Medical Q&A Series | Session 3
September 11 : Kids Challenge & Ride for a Child Car Parade
September 25-26 : Pedal the Cause 2021
September 25 : Livestreamed Inspirational Program
October 31 : Fundraising Closes
November 2 : Medical Q&A Series | Session 4
November 18: Check Presentation