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The Berryman Trail is an approximately 26-mile single-track loop through the Mark Twain National Forest. Run two loops for the 50-mile race, and one loop for the Marathon. The total elevation gain/loss is 2500 ft/2500 ft per loop. The race is run in the clockwise direction. There are plenty of rocks and roots, and at least two opportunities to get your feet wet before and after the Brazil Creek aid station at mile 16 (and mile 42 on 2nd loop). The course crosses many other stream beds that may or may not have water in them depending on recent rainfall.

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