Whether you’re a regular participant or looking to join your first-ever Run, you’ve come to the right place. The Muddy River Marathon is an engaging and fun event, geared towards people of all ages and from all walks of life. The Muddy River Marathon offers three race formats – full marathon, half marathon, and half marathon relay. Our 26.2 mile, 13.1 mile, and half marathon relay courses wind through Cape Girardeau, Missouri. We believe that fitness equals happiness and encourage our participants to challenge their bodies while maintaining a healthy lifestyle.